Natural lung material used for developing lung tissue from embryonic stem cells
A first breakthrough article on using cell-depleted lung for creating new rat lung from embryonic stem cells has been published in a Tissue Engineering.
Embryonic stem cells have the capability to produce virtually any cell and tissue type, but they need the specific environment and chemical commands to direct their transformation into specific cell types and 3-dimensional tissue forms. In order to develop further this technology and clinical applications for engineered lung tissue, options other than synthetical tissue matrices are necessary.
Joaquin Cortiella and his colleagues from University of Texas Medical Branch, Stanford University, Brown Medical School and Duke University made the first effort to produce acellular lung of rats and apply it as a matrix for transforming ESCs into lung tissue. The scientists reported improved cell retention, their differentiation into cell types present in a helathy lung and repopulation of the matrix. They mentioned as well the evidences that the cells are organized into 3-D structures typical for complex tissues and produce the chemical signals and growth factors needed for the functioning and development of lung tissue.
Cortiella and co-authors present the process applied to clean the natural lung tissue from the cell component to produce the growth matrix for ESCs in the article named "Influence of Acellular Natural Lung Matrix on Murine Stem Cell of Embryon. Its Differentiation and Texture Formation."