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Treatment of Patients with Primary Progressive Multiple Sclerosis

Observed were 3 male patients with primary progressive multiple sclerosis. Patients’ age was 31 to 38 years, mean age being 36,4±4,32 years. The diagnosis was established 1,5 to 3 years prior to the cell therapy. In this group of patients, observed was rapid progression of the neurological symptomatology since the first exacerbation, but clear exacerbation and remission were not reported thereafter.

By the beginning of the therapy, the patients demonstrated pronounced symptoms of the brainstem and cerebellum damage as well as spinal disturbances. All the patients reported depression.

Stem cell treatment in this group of patients resulted in termination of the disease progression within 3-6 months, although marked regression of the previous neurological symptoms was not achieved. Reported were significantly improved emotional state and intellectual functioning.

According to MRI results, following gadolinium contrast, registered was decreased number of foci by 51%, and decreased foci volume by 37%.