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Treatment of DMD in patient R. Medical case report No.1

Mr. R., attended by his parents Mrs. Sh. and Mr. A., underwent the first course of stem cell treatment at EmCell clinic. The patient complains of the disorders of gait, weakness, inability to walk up and down stairs, falling down the floor, difficulty to get up from the floor (gets up with the help of arms). As the patient reported, the disease manifested about 2–3 years ago. Diagnosis was established a year ago.

Anamnesis vitae is narrated in details. Last year the progress of the disease was more rapid then before.

Present condition

General condition is satisfactory. Mental and physical development according to the age.
Hyperlordosis, walking is not firm with tiptoes going down. Skin is of a normal color. Lymphatic nodes are not enlarged - by palpation examination. Heart rate is regular, 86 bpm. Tones of the heart are regular, melody is normal, no noise at the auscultation. At percussion lung fields are clear - ordinary sound in all lines. At palpation abdomen is soft, painless. Liver is at the edge of costal arch, with no peculiarity, spleen is out of palpation reach. According to the patient, stools and urination are regular and normal.

 Examination by the neurologist

At the examination the boy is cooperative, acts according to instructions, is concentrated and serious. Visible hyperlordosis at walking. Walks with difficulty, awkwardly, due to the weakness in legs. He cannot squat and gets up with the help of his arms. Muscle strength is substantially reduced in arms and legs, more in right extremities. Hypertrophy of arm and leg muscles. Pseudohypertrophy of calves. Reflexes are weak. In arms S=D. Knee reflexes are D<S. No heel tendon reflex in the right side. Positive Babinsky sign on both sides, S>D. All flexor symptoms (Behterev, Rossolimo, Zhukivsky) are present. Sensitivity is intact. Coordination test—finger-to-nose—is performed satisfactory. Face expression is quite vivid. Eye slots are symmetric, pupils D=S. The movements of eye apples to the full range, but the sight was floating, not fixed in the side positions. Convergence is not sufficient on both sides.

Diagnosis: Muscular dystrophy.

Lab tests (blood count, chemistry, routine urine test, ECG) are normal.

Fetal stem cell therapy is recommended.

R. received a course of fetal stem cell therapy:


1st day of treatment. Transplantation of sample 3038U185 i.v. dropwise, of 2 ml. Implantation of sample 3038UE185 s/c in buttocks, in three depots 0.6 ml each.

2nd day of treatment. Implantation of sample 3038UE185 s/c in buttocks, in two depots 0.9 ml each.

4th day of treatment. Transplantation of sample 3038P6 i.v. dropwise, 1.5 ml. Implantation of sample 3038PM6 s/c in frontal abdomen in two depots 0.8 ml each.

7th day of treatment. Implantation of sample 3038PE6 s/c in buttocks, in three depots, 1.1 ml each.

The cell suspension samples 3038U185, 3038UE185, 3038P6, 3038PM6 and 3038PE6 are certified as follows:

Bacterial sterility test Negative
Prenatal Diagnostics  
Test with cardiolipid antigen Negative
Ami - HIV1/HIV2 Negative
HBsAg Negative
Embryonic Diagnostics  
Enzygnost Ami - HIV1/HIV2 Negative
HBsAg monoclonal Negative
Anti - HBc monoclonal Negative
Anti - CMV/IgG+IgM Negative
Anti - Rubella Virus/IgG Negative
Varicella/Zoster Negative
Toxoplasmosis/IgG Negative

Second examination by the neurologist

Patient's condition has substantially ameliorated - emotional background is more favorable, he is in good mood, more active, moves more, does not fall. The gait has improved, lordosis has diminished, he puts feet straighter, on the full foot (have performed a test of walking on tiptoes and on the heels). Instructions to squat and stand up performs as before. Muscle tone at palpation has improved in forearms and especially in the legs. Tone of both arms did not changed. Reflexes are as before except for the right heel tendon, which is now present. The pathological feet reflexes are less expressed, no Babinsky in the right side. Face expression is more vivid. Eye slots are symmetric, pupils D=S. The movements of eye apples are to the full range, the movements of both eyes are more coordinated and more fixed.

Results of the treatment

Emotional condition has improved, the boy became more active and lively. Gait is more confident, better coordinated, increased strength in forearms and legs. If before the treatment he fell down 3-4 times per day, after the treatment, according to his parents, he did not fall down for the past 3 days. Drags tiptoe less at walking, puts feet more firmly and confidently, lordosis is less expressed. He can walk for long distances with less effort. Corresponding changes in neurological symptoms are described by by the neurologist.

Mr. R. is recommended:

  1. Follow up by the neurologist in the USA.
  2. Diet rich with proteins (veal, fish, mushrooms, etc.).
  3. Regular training including movement activities involving legs and arms.
  4. Avoid infections.
  5. Report (subjective by parents and professional (objective) by neurologist) once a month.
  6. Repeated course of cell therapy in 6–8 months. The exact timing of the visit is to be arranged in accordance with the dynamics of the patient's condition.

Rezultat tretmana fetalnim matičnim ćelijama zavisi od: težine bolesti, starosne dobi pacijenta, doslednosti i privrženosti medikaciji i režimu. Rezultati tretmana, prezentovani na ovom sajtu, su individualni za svaki klinički slučaj.