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Ovarian cancer grade IV, clinical group II

Female patient V., aged 82, stayed at the Department of Gynecology of the Clinical Hospital from January 4, 2002, till March 5, 2002.

Diagnosis: Ovarian cancer grade IV, clinical group II. Concomitant diseases: ischemic heart disease, atherosclerotic miocardiosclerosis, aortal and coronary atherosclerosis, grade 1 chronic circulatory insufficiency. Foreign body (bullet) in the left lung.

On admittance, the patient complained of periodic yellowish vaginal discharge, dull ache in the lower abdomen, loss of weight by 6 to 8 kg, general weakness. On gynecologic examination, USE of small pelvis organs, and abdominal cavity puncture through the posterior vaginal vault, ovary tumors were diagnosed and operated on October 21st, 2002. Taking into account patient’s age and disseminating nature of the disease, the surgery was confined to laparotomy, resection of uterine appendices and metastatic tumor of the radix mesenterii of small bowel. No complications reported during and after the operation.

Pathohistological examination No. 499-540, dated January 21, 2002: low-differentiated solid-papillary carcinoma.

In postoperative period, against the background of detoxication therapy, the patient was subjected to chemotherapy: 120 mg tiofen (intra-abdominal administration through a drainage tube), 800 mg cyclophosphan (intramuscular administration). The treatment was interrupted because of agranulocytosis and hemorrhagic syndrome (macular and petechial rush) developed. Since February 3, the patient received hemostimulating therapy as transfusion of erythromass (150 ml every other day), and 280 ml leukomass in the total amount; daily intramascular injections of 30 mg prednisolon, 0.6 g leukogen, 1.2 g pentoxyl. However, in spite of the therapy, leukocytes counts decreased to 0.5 g/l (February 14, 2002).

On 16th of February, hematopoietic cells of human embryonic liver were transplanted intravenously: sample 3-194-K; volume of cells, 1.5 ml; cell count 34x106/ml; CFU-GM, 40.1x103. The volume of transplanted cells amounted to 30% of the total mass of this sample stored in the cryobank.

After 8 to 10 hours from transplantation, the syndrome of early posttransplantation improvement of general condition was observed in the patient: decrease of weakness, improvement of motional activity, decrease of dyspnea and palpitation, good appetite.

In 3 to 5 days, symptoms of cytostatic agranulocytosis disappeared; no fresh petechiae were reported on skin. Appearance of erythrocytes containing fetal hemoglobin in the blood evidences involvement of fetal hematopoietic cells in hematopoiesis.

The peripheral blood counts of patient V., female, 82 years old with ovarian cancer, grade IV, clinical group II. Cytostatic agranulocytosis. Hemorrhagic syndrome.
Transplantation: February 16, 2002

Date
Indices
22.01 03.02 14.02 16.02
1st day
21.02
5th day
24.02
8th day
27.02
11th day
2.03
14th day
5.03
17th day
Erythrocytes, 1012/l 3.8 2.7 2.9 3.0 3.1 3.1 3.1 3.1 3.2
Hemoglobin, g/l 137 85 91 93 97 100 97 95 93
Color index 0.90 0.95 0.95 0.80 0.90 1.00 0.95 0.95 0.95
Reticulocytes, ppm —* 0.1 0.0 0.0 0.8 2.0 2.0 1.9 1.6
Leukocytes, 109/l 13.8 1.8 0.5** 0.8** 3.1 3.6 3.1 4.7 4.7
Basophils 1 0 0 0 1 1 1 1 1
Eosinophils 0 1 0 4 3 3 5 0 1
Myelocytes 0 0 0 8 13 16 12 6 2
Metamyelocytes 0 0 0 1 2 2 1 2 1
Stem 5 3 9 5 12 15 17 22 20
Segmented 86 70 32 38 33 33 32 42 51
Lymphocytes 5 24 48 35 30 26 27 18 16
Monocytes 3 2 11 9 6 4 5 10 8
Thrombocytes, 109/l 273 90 22 40 54 68 152 98 120
ESR, mm/hr 25 28 20 18 12 5 8 10 15
Erythrocytes containing fetal hemoglobin (ppm) 0.0 0.1 0.7 1.4 3.0 4.2 4.0

* Not identified.
**Differential blood count for calculation of 50 cells.

Fetal stem cells treatment results depend on: disease's severity, age of the patient, adherence for the medications and regime. Treatment results, presented on this site, are individual for each clinical case.