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Amyotrophic lateral sclerosis (ALS, Charkot’s disease, Charkot’s sclerosis, in English-speaking countries – Lou Gehrig’s disease), or motor neuron disease, is a progressing illness that manifests as gradual weakening and atrophy of muscles and lasts for two to five years (in very rare cases – for seven years) with 100% fatal outcome. The clinical picture is compliant with lesion of central and peripheral motor neurons that results in bulbar syndrome as well as muscular atrophy in extremities and respiratory muscles.

Treatment of ALS with stem cells

Indications for ALS treatment with stem cells include confirmed ALS diagnosis, disease progression, and lack of response to existing treatment methods. Prior to year 2000, contraindications to treatment included respiratory failure, grade III, artificial lung ventilation, dysphagia, and presence of gastric stoma. However, nowadays Cell Therapy Center EmCell has experience of treating patients with the above-mentioned complications and disorders that allows for prolonging their life by more than five years.

We have 2 unique treatment programs for the patients suffering from ALS:

1. 2-day treatment with intravenous and subcuteneous use of fetal stem cells: developed for the patients with mild and moderate-to-severe ALS disease course. 

2. 3-day treatment with intrathecal injections: specially developed for the patients with moderate-to-severe ALS disease course. This method allows to increase the effectiveness of therapy among the patients, who have conditions with central nervous system damage. 

After fetal stem cells therapy, 67% of ALS patients note diminishing weakness, improvement of appetite and mood, decrease in intensity of fasciculations and spasticity. Within two months after treatment, increase of motion volume in extremities, decrease in muscular rigidity, normalization of reflexes, decrease in the number of fasciculation zones, better tolerability of daily chores, reduction in intensity of dysphagia and dysarthria (improvement of swallowing, articulation, and clarity in pronunciation of words) have been observed in 34% of patients. Stable positive clinical effect after treatment persists for three to six months.

About 48% of patients need to repeat the course of treatment during the year for retaining the attained positive results. In 25% of cases, patients need periodic injections of stem cells every 1.5–2 years. 

Application of fetal stem cells does not combat the immediate cause of the disease (to date, the exact cause of disease has not been found); however, it exerts substantial influence on links of the pathological process and slows down disease progression. Fetal stem cells therapy improves the quality of life of ALS patients and their ability to work, and prolongs their life.


Experience of ALS treatment at Cell Therapy Center EmCell
Fetal stem cells in amyotrophic lateral sclerosis (poster presentation)
English, pdf, 930 kb


Patient F.T.G., 47. Amyotrophic lateral sclerosis, cervical form, marked flaccid tetraparesis

Patient B.I., 44. ALS, with cervicothoracic involvement, marked tetraparesis, and bulbar palsy. S.p. disc surgery in 2002

Patient S.M., 68. Amyotrophic lateral sclerosis. Bulbar palsy. Spastic tetraparesis

Patient M.A., 76. Motor neuron disease

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