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| Embryonic Stem Cells in New-Onset Type 2 Diabetes Mellitus |
Embryonic Stem Cells in New-Onset Type 2 Diabetes Mellitus
A.I. Smikodub, A.V. Novitskaya
In the course of 1-5 years, observed were18 patients (6 women and 12 men) with diabetes mellitus (DM) complicated by hyperinsulinism and such metabolic disturbance as dyslipidemia, mean age being 43,5±5,8 years, duration of the disease – 1,2±0,5 years. 40% of these patients managed their condition by diet alone, others were undergoing monotherapy with minimal dosages of sulphonylureas. All patients presented with lasting morning hyperglycemia, absence of glycosuria, above normal C-Peptide (5,4±1,3 ng/ml), HbA1C concentration - 8,1±1,5%. All patients showed changed blood lipid profiles with elevated cholesterol level - in the mean by 35%, increased concentration of low-density lipoproteids and very low-density lipoproteids– by mean 30%. Clinical manifestations of the disease were minimal and manifested in the form of functional disturbances and psychophysiological reactions.
Patients were treated by transplantations of hematopoietic and non-hematopoietic mesenchymal and endodermal embryonic stem cells sorted out from growth zones of 4-8 weeks old cadaverous embryos’ internal organs. Suspensions were administered intravenously, in the amount of 0,5-3,0 ml, cell count - 0,1-100x105/ml.
In the course of first post-transplant week, 44% of patients reported elevation of glycemia by 15-25%, then decrease, without additional glycemic therapy. In the course of the first post-transplant month, 84% of patients noted decreased weakness, improved workability, and decreased depression. Decrease of morning hyperglycemia began after 2-3 months, and was accompanied by lowered C-Peptide. Normalization of the above indices, as well as lowering of HbA1C concentration, was reported in 5-7 months after the initial treatment; at the same time period observed was positive tendency in normalization of lipid metabolism. Lasting normalization of carbohydrate and lipid metabolism in 78% of patients was reported after 10-12 months, and was accompanied by weaning off tabloid hyperglycemic medications. Further 2-year observation of 60% of the above patients allows for confirmation of the persistency of the results achieved.
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