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News and articles on liver diseases

Novel stem cell technique may transform liver and pancreatic transplant therapies 14 October 2013

Scientists from the University of Cambridge have found a new way for creating liver and pancreas stem cells – a breakthrough that could significantly transform the future of transplant therapies.

Liver Stem Cells Grown in Culture, Transplanted With Demonstrated Therapeutic Benefit 04 March 2013

The scientists were able to grow liver stem cells in a dish and then transplant them in a specially designed mouse model of liver disease, where they continued to grow and show a modest therapeutic effect.

Japanese Researchers Create the First Primitive Liver from Stem Cells 02 July 2012

For the first time ever, Japanese scientists from Yokohama City University have managed to develop a rudimentary human liver from stem cells.

The First Liver Created from Stem Cells 10 June 2012

For the first time ever, stem cell researchers from Yokohama City University, Japan, succeeded in creating a functioning human liver from stem cells.

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Liver Diseases

Endoscopic implantation of fetal cells

Starting from 1991, we widely use suspensions containing fetal stem cells in our clinical practice. Cell suspensions are administered intravenously, although they also can be implanted in tissues and cavities where they form new cell pools able to endure and function for a long time. For this purpose, the method of endoscopic implantation of fetal stem cells is used. Implantation of fetal stem cells is effective in patients with chronic hepatitis and liver cirrhosis.

Implantation of stem cells for treatment of liver cirrhosis

In patients with liver cirrhosis complicated with portal hypertension, laparoscopy is carried out. Layers of the falciform ligament of the liver are separated with the small amount of air (5–10 ml). Stem cells derived from tissues of a 5–8 week-old embryo are implanted into resulting cavities: embryonic liver cells (number of cells – 10–80x106/ml) in 2–3 depots of total volume of 1–3 ml, and hemopoetic stem cells (number of cells – 60–220x106/ml) in 4–6 depots of total volume of 1–4 ml.

In 8–12 hours after implantation of fetal stem cells, the syndrome of early post-transplantation improvement, as well as the syndrome of psycho-functional changes (decrease in intensity of somatic depression, improvement of the emotional status, cognition, and memory) are observed in all cases.

On the 3rd–5th days after transplantation, reduction in amount of free liquid in abdominal cavity is noted. In 35% of patients after implantation free liquid is not being found for 3–6 months, and no diuretic therapy is required. In 65% patients the amount of liquid persists at the level of 100–300 ml which requires minor diuretic therapy.

In all patients blood aldosterone levels go down to normal and are subsequently preserved for 4–6 months. Functional parameters of liver cells improve in 3–4 weeks after treatment. Bilirubin metabolism is normalized; that is reflected by decrease in blood enzyme (transaminase) levels. Total count of CD3+, CD4+, and CD8+ lymphocytes and NK cells increases; this fact represents immunocorrection effect of fetal stem cells.

Duration of the treatment course for liver disease at Cell Therapy Center EmCell, as a rule, totals 2 days.
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