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Сonditions and diseases
AIDS/HIV ALS Alzheimer's Disease Anemia Anti-Aging Treatment Arterial Hypertension Cancer Diabetes Treatment Eye Diseases Idiopathic Encephalopathy Ischemic Heart Disease Liver Diseases MD Treatment Multiple Sclerosis Treatment Parkinson Treatment Rheumatoid Arthritis SMA Ulcerative Colitis. Crohn’s DiseaseThe second course of treatment for idiopathic encephalopathy in patient J.S.M.
We had the honour to accept at EmCell clinic Mr. J.S.M., DOB September 5, 1936. Mr. J.S.M.was attended by his son Mr. J.S.M., Jr. This was the second visit of Mr. J.S.M. to our clinic.
We established the following diagnosis: Idiopathic encephalopathy, involution of left frontal and temporal lobe, right cerebellum, initial signs of dementia, aphasia, mild ataxia.
From the internist's point of view Mr. J.S.M. is a man older than his age, of athletic habit, safe in the somatic sense. Pulse regular 64–76 beats per minute, normal blood pressure 75–80 to 115–120 mm Hg. Heart tones were normal including sound and melody. Above the lungs there a clear percussion sound. Palpation of abdomen revealed no particularities. Skin was clear.
Since the last visit we admitted positive changes in his walk (more confident), speech (increased amount, fluency, readiness for communication), behavior (more active and completely included in all happening around), mood (optimistic, ready for humor, with no complaints), etc.
Tests:
The state of the patient improved comparatively to previous examination. He had no complains. Focal organic changes of nerve system were not revealed – he is stable in the Romberg test, the adiadochokynesis is absent. The walk without particularities. Synkinesis of arm by the walk is satisfactory.
Considering effect of the treatment it is recommended to continue the therapy.
Mr. J.S.M. received a course of cell therapy. Action of the cell suspensions was directed to the restitution of nerve connections, normalization of hematoencephalic barrier functions, removing of immune aggression against brain cells and to the restitution of micro circulation.
The 1st day. Implantation of the cell suspension sample 3038AM522 subcutaneously in the frontal abdomen in two depots in amount 2 ml each.
The 2nd day. Transplantation of the cell suspension sample 3038A522 IV, amount 3.5 ml. Implantation of the cell suspension sample 3038AM522 subcutaneously in the frontal abdomen in two depots in amount 1.5 ml each.
The 3rd day. Transplantation of the cell suspension sample 3038A522 IV, amount 2.5 ml.
The 4th day. Transplantation of the cell suspension sample 3038A117 IV, amount 2.6 ml.
Implantation of the cell suspension sample 3038AM117 subcutaneously in the frontal abdomen in two depots in amount 1.3 ml each.
The cell suspension samples 3038AM522, 3038A522, 3038AM117 and 3038A117 possess the mentioned above functional activity and are certified as follow:
The treatment included also Cavinton sol 2.0 Sodium chloride sol. 0.9% – 100.0 IV 1 time per day, 5 injections. On the 4th day he also began treatment with Nootropil (Pyracetam) 0.4 x 2 times per day.
Recommendations:
We established the following diagnosis: Idiopathic encephalopathy, involution of left frontal and temporal lobe, right cerebellum, initial signs of dementia, aphasia, mild ataxia.
From the internist's point of view Mr. J.S.M. is a man older than his age, of athletic habit, safe in the somatic sense. Pulse regular 64–76 beats per minute, normal blood pressure 75–80 to 115–120 mm Hg. Heart tones were normal including sound and melody. Above the lungs there a clear percussion sound. Palpation of abdomen revealed no particularities. Skin was clear.
Since the last visit we admitted positive changes in his walk (more confident), speech (increased amount, fluency, readiness for communication), behavior (more active and completely included in all happening around), mood (optimistic, ready for humor, with no complaints), etc.
Tests:
- Average blood count: Erythrocytes 4.2x1012/l, Hb 137 g/l, color index 0.9, thrombocytes 200x109/l, leukocytes 3.9x109/l, stab neutrophils 2%, segmented neutrophils 59%, eosinophiles 2%, lymphocytes 32%, monocytes 5%, ESR 3 mm/hr.
- Blood Chemistry: Bilirubin total 15.0 mmol/l, direct – neg., indirect 15.0 mmol/l, ALT 0.45 mmol/l, ACT 0.24 mmol/l, cholesterine 6.0 mmol/l, urea 12.5 mmol/l, creatinine 0.130 mmol/l.
- ECG: regular sinus rhythm, signs of mild changes of myocardium.
The state of the patient improved comparatively to previous examination. He had no complains. Focal organic changes of nerve system were not revealed – he is stable in the Romberg test, the adiadochokynesis is absent. The walk without particularities. Synkinesis of arm by the walk is satisfactory.
Considering effect of the treatment it is recommended to continue the therapy.
Mr. J.S.M. received a course of cell therapy. Action of the cell suspensions was directed to the restitution of nerve connections, normalization of hematoencephalic barrier functions, removing of immune aggression against brain cells and to the restitution of micro circulation.
The 1st day. Implantation of the cell suspension sample 3038AM522 subcutaneously in the frontal abdomen in two depots in amount 2 ml each.
The 2nd day. Transplantation of the cell suspension sample 3038A522 IV, amount 3.5 ml. Implantation of the cell suspension sample 3038AM522 subcutaneously in the frontal abdomen in two depots in amount 1.5 ml each.
The 3rd day. Transplantation of the cell suspension sample 3038A522 IV, amount 2.5 ml.
The 4th day. Transplantation of the cell suspension sample 3038A117 IV, amount 2.6 ml.
Implantation of the cell suspension sample 3038AM117 subcutaneously in the frontal abdomen in two depots in amount 1.3 ml each.
The cell suspension samples 3038AM522, 3038A522, 3038AM117 and 3038A117 possess the mentioned above functional activity and are certified as follow:
| Bacterial sterility test | Negative |
| Prenatal diagnostic | |
| Test with cardiolipid antigen | Negative |
| Anti-HIV1/HIV2 | Negative |
| HBsAg | Negative |
| Fetal diagnostic | |
| Enzygnost Anti-HIV1/HIV2 | Negative |
| HBsAg monoclonal | Negative |
| Anti-HBc monoclonal | Negative |
| Anti-CMV/IgG+IgM | Negative |
| Anti-Rubella Virus/IgG | Negative |
| Varicella/Zoster | Negative |
| Toxoplasmosis/IgG | |
The treatment included also Cavinton sol 2.0 Sodium chloride sol. 0.9% – 100.0 IV 1 time per day, 5 injections. On the 4th day he also began treatment with Nootropil (Pyracetam) 0.4 x 2 times per day.
Recommendations:
- The observed improvement of the patient's condition is good prognostic sign for the development of the curative effect. It is recommended that examination and the next course of treatment by means of cell therapy should be in in 6–8 months at EmCell clinic.
- We recommend to continue the started course of Pyracetami (Nootropili) – preparation that improves metabolism in the large brain neurons – in total dosage 0.4 (1 capsule 3 times per day) and Cavinton - preparation, that improves brain circulation, opens collateral vessels and restores micro circulation. The course may consist of 5-8 intravenous injections and then of 4–6 tablets per day during 2–3 months.
- Among the additional therapy we recommend to continue only sleeping or sedative preparation before night sleep.
- Before next visit to our clinic we recommend to make a fresh MRT-test.