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The researchers from University of British Columbia, Canada, have found a new quicker way to develop insulin producing beta cells from stem cells.
An Egyptian team of researchers in their attempt to develop stem cell treatment for diabetes produced insulin producing cells from stem cells in diabetic mice.
The researchers were working with mice cells, but they hope that the method may be developed in the future to give cure for diabetes to the humans.
Millions of diabetics around the world are threatened with vision loss, a secondary effect of their disease, but researchers are exploring whether stem cells can be used to treat or prevent this diabetic complication.All news
Diabetes mellitus (DM) is one of the prevailing hormonal diseases. It is often called a “non-infectious epidemic disease of the 21st century”. 200 million people have diabetes worldwide, and their number is increasing. By 2025, the number of diabetes mellitus sufferers is expected to increase by 50%.
Diabetes mellitus is characterized by a high blood sugar (glucose) level resulting from either insufficient insulin production in the body (type I diabetes) or body cells improper response to the produced insulin (type II diabetes).
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We have developed a fetal stem cell transplantation-based method (excluding pancreatic beta-cells) for diabetes treatment. This method has proven to be effective for diabetes types I and II treatment and is protected by patents of many countries. Stem cell treatment of diabetes results in pronounced hypoglycemic effect, i.e. decrease of blood sugar level, allowing to reduce the dose of exogenous insulin by 50–70%. Diabetes treatment with fetal stem cells induces long-term clinical remission in more than half of cases.
Stem cell treatment of diabetes leads to significant improvement in patient’s condition. In some cases at the early stages of the disease, it may result even in the full recovery. After the stem cell therapy, diabetes mellitus patients report normalization of immunological and hematological indices, reduced manifestations of micro- and macroangiopathy and trophic disturbances, restoration of workability. In case of treatment the disease progression is hindered, and periods of remission become 2–3 times longer. Severity and frequency of diabetes complications decrease. Life quality and average life expectancy increase.
Major effects of diabetes mellitus treatment with stem cells are listed below.
Decrease of glycemia in patients with new-onset insulin-dependent diabetes mellitus
Within 2–3 months after the stem cell treatment, in 100% of cases the dosage of administered insulin gradually decreased. With the average initial insulin dosage at 0.76±0.06 units/kg/day, maximum dosage decrease amounted to 20–100% (41% on average), lasting for 14 to 90 days (59.0±4.3 days on average). In 65% of cases, diabetes treatment resulted in clinical remission with exogenous insulin dosage dropping to less than 0.4 units/kg/day, or insulin therapy completely discontinued. Remission lasted 5 to 14 months.
The syndrome of the early post-transplantation improvements
The syndrome of the early post-transplantation improvements includes weakness decrease, restoration of work capaсity, appetite and sleep. The syndrome is observed in 63% of cases.
Improvement of psycho-physiological condition
The syndrome of psycho-physiological changes includes improvement of thinking and mental capacity, inburst of energy, disappearance of anxiety, depression decrease, etc. The syndrome has been noted in 48% cases.
Diabetes treatment with fetal stem cells leads to restoration of immunological parameters. Lymphocyte count, T-lymphocytes and subpopulations of T-lymphocytes normalize. B-lymphocytes count decreases by 30–60%. The immunocorrecting effect lasts for 3 to 8 months.
Reconstitution of hematopoiesis
Within 1–1.5 months after the stem cell treatment of patients with diabetic glomerulosclerosis complicated by chronic renal failure (I, II and III degrees) and anemic syndrome, restoration of hematopoiesis, normalization of erythrocyte count and hemoglobin were observed. This effect is maintained up to 12 months.
Improvement of dystrophic disorders and trophic disturbances
After the transplantation of fetal stem cells, trophic ulcers disappear, microcirculation improves, and infectious skin lesions, fungus dermatitis, cutaneus lychenisation and lipoatrophic lesions decrease.
Stem cell treatment of diabetes is indicated at all stages of the disease. It is, however, the most effective in the cases of:
The diabetes treatment course at Cell Therapy Center EmCell, as a rule, lasts for 2 days.
If you would like to undergo diabetes mellitus treatment at our center, for preliminary analysis of your case, please, fill in the attached form and send it back to: firstname.lastname@example.org
Fetal Stem Cell Transplantation in Metabolic Syndrome. Poster session.
English, jpg, 2.3 Mb
Fetal Stem Cells in Diabetic Nephropathy. Poster session.
English, jpg, 800 kb
Fetal Stem Cell Transplantation in Diabetes Mellitus. Poster session.
English, pdf, 1.6 Mb
Treatment of type I diabetes mellitus in patient D.A.T.
Treatment of type I diabetes mellitus in patient P.I.N.
Treatment of type II diabetes mellitus, severe course
Treatment of type II diabetes mellitus, moderate course
The letter from the patient M.A. after the first course of treatment
Feedback of the patient Z. suffering from moderate type 2 diabetes mellitus
Feedback of the patient A. suffering from advanced type 2 diabetes mellitus
The letter from J. Sch.-J. suffering from diabetes