A stem cell treatment for ALS and other incurable neurodegenerative diseases gets early efficacy proofs and is entering Phase II clinical trials in the US.
In 11 independent studies, a consortium of ALS researchers shows that transplanting neural stem cells into the spinal cord of an ALS mouse model slows disease onset and progression, improves motor function, and significantly prolongs survival.
A clinical trial of stem cell therapy for ALS patients conducted by Israel-based BrainStorm Cell Therapeutics shows the treatment to be well-tolerated, safe and not presenting risk of side-effects, an interim safety review says.
According to the phase 1 study by Neuralstem (USA), transplantation of stem cells into the lumbar region of the spinal cord has proven safe and was well-tolerated by ALS patients who participated in the trial.All news
Indications for ALS treatment with stem cells include confirmed ALS diagnosis, disease progression, and lack of response to existing treatment methods. Prior to year 2000, contraindications to treatment included respiratory failure, grade III, artificial lung ventilation, dysphagia, and presence of gastric stoma. However, nowadays Cell Therapy Center EmCell has experience of treating patients with the above-mentioned complications and disorders that allows for prolonging their life by more than five years.