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Сonditions and diseases
AIDS/HIV ALS Alzheimer's Disease Anemia Anti-Aging Treatment Arterial Hypertension Cancer Diabetes Treatment Eye Diseases Idiopathic Encephalopathy Ischemic Heart Disease Liver Diseases MD Treatment Multiple Sclerosis Treatment Parkinson Treatment Rheumatoid Arthritis SMA Ulcerative Colitis. Crohn’s DiseaseClinical AIDS
Female patient T., 37 years old, was admitted to the AIDS Department of the Research Institute of Epidemiology and Infectious Diseases on February 23, 2003.
Diagnosis: Clinical AIDS; reconvalescent of pneumocystic pneumonia; chronic smoker's bronchitis; post-encephalitis condition; candidiasis of intestine and respiratory tracts; chronic gastritis in unstable remission; chronic cholecystitis in unstable remission.
HIV infection was revealed in 2000; the patient was treated in Moscow till September, 2002. Her first stay with the AIDS Department of the Research Institute for Epidemiology and Infectious Diseases lasted from September 17 till October 26, 2002. The patient suffered from pneumocystic pneumonia.
On October 23, 2002, the patient was transferred to Intensive Care department with herpetic encephalitis. Here, after the spinal puncture, spastic paraplegia and fallopian neuritis developed as a result of encephalitis.
The patient complained permanent headaches that were periodically aggravated, accompanied by nausea and sometimes by vomiting, as well as vertigo and periodic losses of consciousness. In addition, the patient suffered from cough accompanied by expectoration of small amounts of sputum, sensation of pain in bones and joints, weakness of muscles inof lower extremities (walking while holding a support), facial asymmetry (right-side neuritis of the facial nerve). Body temperature periodically increased up to 39° C.
Objectively: skin and mucosa were pale and clean; small peripheral lymph nodes (up to 0.5 cm in diameter), movable, elastic, painless. Heart sounds were clear and rhythmic; respiration in lungs was rough, with diffused dry rales over the total surface.
The abdomen was soft and sensitive to palpation in the epigastric and right hypochondrium areas; stools and diuresis without any peculiarities.
The first transplantation of the cell suspension prepared from hematopoietic cells of human embryonic liver was carried out on March 4, 2003. The suspension was administered in an amount of 2.5 ml.
After transplantation, positive effects were observed, i.e. improvement of general condition, emotional tonus and appetite. After several days, the cough decreased; it became easier for the patient to walk; the fever diminished. Rough respiration was still present in the lungs, however no rales was auscultated.
On April 29, 2003, repeated transplantation was carried out (the same sample, in amount of 2.5 ml). The patient was discharged on April 30, 2003 (for family reasons) in the satisfactory condition.
The patient stayed once again at the AIDS Department from May 13 till July 17, 2003. Headache, vertigo, pain in bones and joints were still present. Body temperature however did not increase; good appetite and sleep were observed; facial asymmetry diminished, cough disappeared; the patient could walk small distances without any support.
After her discharge on July 17, 2003, the patient stayed at home in the city of Odessa where she had herpes zoster of the hairy part of the head, with body temperature increase and encephalopathy. Breakouts continued till August 4, 2003.
On September 9, 2003, the patient was admitted to the AIDS Department with complaints of referred headache to right and left orbital cavities, pain and hinderedpainful and stiff movements in joints, increasing body temperature up to 37.3 to 38.2o C, epigastric pain, and cough accompanied by expectoration of thick of sputum having a purulent nature. Rough respiration was auscultated in the lungs together with dry rales on both sides (October 19, 2003: pneumocysts in 48% of visual fields).
On November 5, 2003, the third transplantation of the cell suspension of the same sample was carried out (1.5 ml). On November 9, 2003, cough decrease was noted; body temperature was 37.2o C. No pneumocysts were revealed. The patient was discharged on November 11, 2003 in the satisfactory state.
Table shows the results of laboratory and immunological tests.
Immunology of patient T., female
Patients lives in city of Odessa and several times per year informs about her state. She is regularly examined once a year on the base of AIDS Department of the Kiev Research Institute for Epidemiology and Infectious Diseases by our doctors. She received altogether six Cell transplantations, last one in August 2007. For this time progress of AIDS symptoms was not observed. Among concomitant diseases there was candidiasis of mouth cavity, Frequent exacerbation of chronic bronchitis caused by common infections. She is active, engaged in retail trade.
During all course of the disease until present time patient refused to take any antiviral preparations. She does not tolerate AZT as it was revealed when short 2 months course of AZT was prescribed in 2002 year.
At present, the state of the patient is satisfactory. Observation is being continued.
Diagnosis: Clinical AIDS; reconvalescent of pneumocystic pneumonia; chronic smoker's bronchitis; post-encephalitis condition; candidiasis of intestine and respiratory tracts; chronic gastritis in unstable remission; chronic cholecystitis in unstable remission.
HIV infection was revealed in 2000; the patient was treated in Moscow till September, 2002. Her first stay with the AIDS Department of the Research Institute for Epidemiology and Infectious Diseases lasted from September 17 till October 26, 2002. The patient suffered from pneumocystic pneumonia.
On October 23, 2002, the patient was transferred to Intensive Care department with herpetic encephalitis. Here, after the spinal puncture, spastic paraplegia and fallopian neuritis developed as a result of encephalitis.
The patient complained permanent headaches that were periodically aggravated, accompanied by nausea and sometimes by vomiting, as well as vertigo and periodic losses of consciousness. In addition, the patient suffered from cough accompanied by expectoration of small amounts of sputum, sensation of pain in bones and joints, weakness of muscles inof lower extremities (walking while holding a support), facial asymmetry (right-side neuritis of the facial nerve). Body temperature periodically increased up to 39° C.
Objectively: skin and mucosa were pale and clean; small peripheral lymph nodes (up to 0.5 cm in diameter), movable, elastic, painless. Heart sounds were clear and rhythmic; respiration in lungs was rough, with diffused dry rales over the total surface.
The abdomen was soft and sensitive to palpation in the epigastric and right hypochondrium areas; stools and diuresis without any peculiarities.
The first transplantation of the cell suspension prepared from hematopoietic cells of human embryonic liver was carried out on March 4, 2003. The suspension was administered in an amount of 2.5 ml.
After transplantation, positive effects were observed, i.e. improvement of general condition, emotional tonus and appetite. After several days, the cough decreased; it became easier for the patient to walk; the fever diminished. Rough respiration was still present in the lungs, however no rales was auscultated.
On April 29, 2003, repeated transplantation was carried out (the same sample, in amount of 2.5 ml). The patient was discharged on April 30, 2003 (for family reasons) in the satisfactory condition.
The patient stayed once again at the AIDS Department from May 13 till July 17, 2003. Headache, vertigo, pain in bones and joints were still present. Body temperature however did not increase; good appetite and sleep were observed; facial asymmetry diminished, cough disappeared; the patient could walk small distances without any support.
After her discharge on July 17, 2003, the patient stayed at home in the city of Odessa where she had herpes zoster of the hairy part of the head, with body temperature increase and encephalopathy. Breakouts continued till August 4, 2003.
On September 9, 2003, the patient was admitted to the AIDS Department with complaints of referred headache to right and left orbital cavities, pain and hinderedpainful and stiff movements in joints, increasing body temperature up to 37.3 to 38.2o C, epigastric pain, and cough accompanied by expectoration of thick of sputum having a purulent nature. Rough respiration was auscultated in the lungs together with dry rales on both sides (October 19, 2003: pneumocysts in 48% of visual fields).
On November 5, 2003, the third transplantation of the cell suspension of the same sample was carried out (1.5 ml). On November 9, 2003, cough decrease was noted; body temperature was 37.2o C. No pneumocysts were revealed. The patient was discharged on November 11, 2003 in the satisfactory state.
Table shows the results of laboratory and immunological tests.
Immunology of patient T., female
| Date | CD3+ abs in m3 % |
CD4+ abs. in m3 % |
CD8+ abs. in m3 % |
HLADR abs. in m3 % |
CD4/CD8 | SIg abs. in m3 % |
| 25.02.03 | 950 43.2 |
442 20.1 |
851 38.7 |
85 3.9 |
0.52 | 466 21.2 |
|
04.03.03 1st transplantation |
||||||
| 09.03.03 | 407 23.2 |
414 23.7 |
405 23.2 |
453 25.9 |
1.02 | 252 14.4 |
| 18.03.03 | 1,807 42.3 |
1,115 26.1 |
572 13.4 |
594 19.9 |
1.94 | 449 10.5 |
| 01.04.03 | 1,690 47.1 |
793 22.1 |
377 10.5 |
384 10.7 |
2.1 | 459 12.8 |
| 13.04.03 | 1,512 39.8 |
604 15.9 |
840 22.9 |
380 10.2 |
0.69 | 433 11.4 |
|
29.04.03 2nd transplantation |
||||||
| 18.05.03 | 1,641 40.1 |
528 12.9 |
810 19.8 |
394 8.9 |
0.65 | 438 10.7 |
| 01.06.03 | 1,016 36.1 |
439 15.6 |
632 26.4 |
468 16.6 |
0.59 | 335 11.9 |
| 08.06.03 | 349 34.4 |
211 21.2 |
130 13.0 |
120 12.0 |
1.63 | 60 6.0 |
| 01.07.03 | 497 34.9 |
369 25.9 |
310 21.8 |
219 15.4 |
1.19 | 233 16.4 |
| 21.09.03 | 838 47.9 |
393 22.5 |
213 12.2 |
497 28.4 |
1.89 | 385 22.0 |
| 07.10.03 | 464 40.6 |
243 21.3 |
297 26.0 |
65 5.7 |
0.8 | 275 24.1 |
| 02.11.03 | 479 31.5 |
247 16.3 |
223 14.7 |
184 12.1 |
1.8 | 197 13.0 |
|
05.11.03 3rd transplantation |
||||||
| 11.11.03 | 512 33.7 |
340 22.4 |
275 18.1 |
165 10.9 |
1.23 | 82 5.4 |
| 23.11.03 | 319 31.6 |
87 9.9 |
83 9.5 |
183 20.8 |
1.04 | 91 10.4 |
| 07.12.03 | 284 22.1 |
160 12.5 |
204 15.9 |
90 7.0 |
0.78 | 137 10.7 |
| 06.01.04 | 763 43.9 |
347 20.0 |
507 29.2 |
330 19.0 |
0.68 | 358 20.5 |
| 10.02.04 | 1,184 70.0 |
159 9.4 |
487 28.8 |
398 23.5 |
0.33 | 311 18.4 |
| 17.03.04 | 1,113 51.4 |
400 18.5 |
1,072 49.5 |
258 11.9 |
0.37 | 147 6.8 |
| 04.10.04 | 737 67.0 |
308 28.0 |
544 55.0 |
176 16.0 |
0.51 | 34 3.1 |
| 15.03.05 | 499 54.0 |
143 15.5 |
323 35.0 |
213 23.0 |
0.44 | 240 26.0 |
|
16.03.05 4th transplantation |
||||||
| 20.04.05 | 1,003 59.0 |
357 21.0 |
510 30.0 |
255 15.0 |
0.70 | 408 24.0 |
| 15.09.05 | 928 76.0 |
379 31.0 |
501 41.0 |
220 18.0 |
0.76 | 354 29.0 |
| 13.04.06 | 619 68.0 |
291 32.0 |
528 58.0 |
155 17.0 |
0.55 | 200 22.0 |
|
16.04.06 5th transplantation |
||||||
| 17.05.06 | 862 57.0 |
423 28.0 |
650 43.0 |
302 20.0 |
0.65 | 348 23.0 |
| 14.10.06 | 718 54.0 |
359 27.0 |
625 47.0 |
359 27.0 |
0.57 | 253 19.0 |
|
06.08.07 6th transplantation |
||||||
| 23.05.09 | Observation is being continued. | |||||
Patients lives in city of Odessa and several times per year informs about her state. She is regularly examined once a year on the base of AIDS Department of the Kiev Research Institute for Epidemiology and Infectious Diseases by our doctors. She received altogether six Cell transplantations, last one in August 2007. For this time progress of AIDS symptoms was not observed. Among concomitant diseases there was candidiasis of mouth cavity, Frequent exacerbation of chronic bronchitis caused by common infections. She is active, engaged in retail trade.
During all course of the disease until present time patient refused to take any antiviral preparations. She does not tolerate AZT as it was revealed when short 2 months course of AZT was prescribed in 2002 year.
At present, the state of the patient is satisfactory. Observation is being continued.