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May 22, 2000
We had honor to accept at our Cell Therapy Clinic of National Medical University and Embryonic Tissues Center "EmCell" Mr. R. (DOB - March 19, attended by his parents Mrs. Sh. (DOB - January 28, 1972) and Mr. A. (DOB - March 29,1961). Period of treatment -May 15-22, 2000.
Diagnosis: Duchenne Muscular Dystrophy
The patient complains of the walking disorders, muscle weakness, inability to walk up and down stairs, to get up from the floor without help. Life history is narrated in details in the description from May 26, 1998.
05.16.00. Examination by Neurologist, Dr. Natalia Sedeleva, MD, Ph.D.
According to the parents, for half a year the condition of the boy has been satisfactory. Starting from March, some decrease in the quality of movement activity was observed. Within half a year the boy has gained 11 pounds (5 kg) in weight and 2-3 inches (7.5 cm) in height. The walking had improved - the expression of lordosis has diminished, he walks stepping with the full foot, can run. The strength in arms and legs has increased, hypotrophy of shoulder girdle muscles, and especially in pelvic girdle, has diminished. Arm reflexes D=S, knee - D=S, heel S=D; plantar reflexes are reported periodically. Gets up from the bed by himself. Sight is fixed, movements of eye apples are to a full range, convergence is good. The boy is in good spirits, attentive, does well in his studies. So, there is obvious positive progress in physical activity as well as growth and weight gain.
Diagnosis is the same - Muscular dystrophy.
Lab tests (blood count, chemistry, routine urine test) were normal.
Recommendations: continue Cell Therapy.
Mr.R. received a course of cell therapy:
05.16.00. Transplantation of sample 30381212 i.v. dropwise, 0.9 ml. Implantation of the sample 3038IM212 s/c in frontal abdomen, in two depots, 0,7 ml each. Implantation of sample 3038IE212, s/c in buttocks, in two depots, 1.0 ml each.
05.17.00. Transplantation of sample 30381212 i.v. dropwise, 0.9 ml. Implantation of sample 3038IM212 s/c in frontal abdomen, in two depots, 0,7 ml each. Implantation of sample 3038IE212, s/c in buttocks, in two depots, 0.8 ml each.
05.19.00. Transplantation of sample 3038A498 i.v. dropwise, 2.0 ml. Implantation of sample 3038AM498, s/c in frontal abdomen, in two depots, 1,1 ml each. Implantation of sample 3038IE406, s/c in buttocks, in two depots, 0.9 ml each.
05.20.00. Transplantation of sample 3038A498 i.v. dropwise, 1.0 ml. Implantation of sample 3038AE498, s/c in frontal abdomen, in two depots, 0.9 ml each.
05.22.00. Implantation of sample 3038AE498, s/c in frontal abdomen, in two depots, 1.2 ml each.
The Cell suspension samples 30381212, 3038IM212, 3038IE212, 3038A498, 3038AM498, 3038IE406, and 3038AE498 are certified as follows:
| Bacterial sterility test |
Negative |
| Prenatal Diagnostics |
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| Test with cardiolipid antigen |
Negative |
| Ami - HIV1/HIV2 |
Negative |
| HBsAg |
Negative |
| Embryonic Diagnostics |
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| Enzygnost Ami - HIV1/HIV2 |
Negative |
| HBsAg monoclonal |
Negative |
| Anti - HBc monoclonal |
Negative |
| Anti - CMV/IgG+IgM |
Negative |
| Anti - Rubella Virus/IgG |
Negative |
| Varicella/Zoster |
Negative |
| Toxoplasmosis/IgG |
Negative |
Results of the Treatment
During the course of treatment were observed the following positive changes: increase of the range of activity, good spirits.
Mr. R. is recommended:
1. Follow-up by the neurologist in the USA.
2. Diet rich in proteins (veal, fish, mushrooms, etc.).
3. Regular training in movement of legs and arms. Monthly measurements of weight and height.
4. Avoid infections.
5. Repeated course of cell therapy in October 2000. The exact timing of the visit is to be arranged in accordance with the changes of the patient's condition.
Head of the Cell Therapy Clinic of National Medical University and Embryonic Tissues Center "EmCell"
Professor Alexander Smikodub
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