Diagnosis:

Multiple sclerosis of cerebrospinal type. Concomitant divergent strabismus OS. Middle range nystagmus. Hypermetropic astigmatism. Angiopathy of retina. Initial maculodystrophy of both eyes.

We had an honour to accept at our Cell Therapy Clinic of National Medical University and “EmCell” Center Mr. D.C., DOB November 3, 1959. Mr. D.C. stayed at Cell Therapy Clinic from 1 to 6 of December, 1996.

We have established the following diagnosis:

Multiple sclerosis of cerebrospinal type. Concomitant divergent strabismus OS. Middle range nystagmus. Hypermetropic astigmatism. Angiopathy of retina. Initial maculodystrophy of both eyes.

Tests:

12.02.96. Average blood count:

Erythrocytes 4.6*10¹²/l, Hb 152 g/l. color index 1.0, thrombocytes 210x10⁹/l, leukocytes 6.8x10⁹/l, stab neutrophils 4%, segmented neutrophils 54%, eosinophiles 2%, lymphocytes 39%, monocytes 1%, ESR 3 mm/hr.

12.04.96. Average blood count:

Erythrocytes ....*10¹²/l, Hb .. g/l. color index ..., thrombocytes ...*10⁹/l, leukocytes ...*10⁹/l, stebcellsstab neutrophils ..%, segmented neutrophils ..%, eosinophiles ..%, lymphocytes ..%, monocytes ..%, ESR .. mm/hr.

12.02.96. Blood Chemistry:

Bilirubin total 21.7 mmol/l, direct neg., indirect 21.7 mmol/l, ALT 0.34 mmol/l, ACT 0.21 mmol/l, thymol test 1.7 units, urea 5.8 mmol/l, creatinine 0.062 mmol/l.

12.02.96. Blood glucose - 3.9 mmol/l.

12.03.96. Common urine analysis:

Volume - 60.0 ml, protein - neg., sugar - neg., flat epithelium in small quantity, leukocytes 2-3 in the field of vision.

12.02.96. ECG:

Regular sinus rhythm. Normal position of the heart axis. Dystrophic changes in myocardium.

12.02.96. Neurological examination.

The patient’s health condition has gotten noticeably better, comparing to the previous examination in October 1996 (e.g. The patient is dressing himself and eating without help). The horizontal middle range nystagmus the by the side look is still continued, rhinolaly is decreased. Tonus in arms is normal, in legs - enhanced, s>d. Enhanced reflexes, s>d, both legs - Babinski’s sign. No disturbances of motional coordination found. The pain sensitivity is intact. Conclusion: multiple sclerosis of cerebrospinal type. Recommended to continue the course of the Cell Therapy.

Cell Therapy:

12.02.96. Implantation of the Cell suspension sample 3038KM52 subcutaneously in the frontal abdomen in two depots in amount of 1.3 ml each.

12.03.96. Implantation of the sample 3038K52 drop-wise intravenously in amount of 2.4 ml; implantation of the sample 3038KM52 subcutaneously in the frontal abdomen in two depots in amount of 0.7 ml each.

12.04.96. Implantation of the sample 3038K52 dropwise intravenously in amount of 1.5 ml; implantation of the sample 3038KM52 subcutaneously in the frontal abdomen in two depots in amount of 1.5 ml each.

12.05.96. Implantation of the sample 3038B460 dropwise intravenously in amount of 2.2 ml; implantation of the sample 3038BM60 subcutaneously in the frontal abdomen in two depots in amount of 1.8 ml each.

Mr. D.C. is recommended to

1. To make monthly peripheral blood counts.

2. To take the peripheral blood uncolored smears fixed by 960 spirits monthly. To keep these smears and give them all together over to the Cell Therapy Clinic.

3. To make the next visit to the Cell Therapy Clinic in autumn of 1997.

Head of the Cell Therapy Clinic
of National Medical University and Center "EmCell"
professor Alexander Smikodoub.