Idiopathic encephalopathy, involution of left frontal and temporal lobe, right cerebellum, initial signs of dementia, aphasia, mild ataxia.
We had the honour to accept at our Cell Therapy Clinic of National Medical University and Center 'EmCell' Mr. J.S.M., DOB September 5, 1936. Mr. J.S.M. stayed at Cell Therapy Clinic from 1 to 5 of July, 1996. Mr. J.S.M.was attended by his son Mr. J.S.M., Jr.
This was the second visit of Mr. J.S.M. to our clinic. Before the firs visit we received and took into consideration the file covering the history of the case for recent years. The file included valuable records by:
- Carroll Ramsayer M.D. (Neurology) 11-13 and 12-13 1994
- Maynard Levenick M.D. (Radiology) 11-4-94 (MRI)
- Diana Van Lanker Ph.D. (Neurolinguistics) 5-2-95
- Jason S. Kahan Ph.D. (Psychology) 12-1-94
- Jeffrey Shaeffer, Ph.D. (Neuropsychology) 9-18-95
- Victor Henderson, M.D. (Neurology) 1-23 and 5-2 1995
- Scott Grafton, M.D. (Nuclear Neurology) 4-4-95 (PET)
- Steven Brigham, Ph.D (Psychology) 3-21-95
- R.D.Jones, Ph.D. (Neurology) 10-2-95
- Thomas J. Grabowsky (Neurology) 10-3-95
- Ismael Mena, M.D. 1-24-96 (Brain Spect)
- George Chow M.D. 4-25-96, 4-27-96
- Ulf Lando, M.D. 4-24-96
- Ramzi Kiriakos M.D. 4-23-96
- Ed Jefferson, M.D. 4-26-96 (MRI)
- Faud F. Rafidi M.D. 5-9-96.
Chemistry and Serology Lab Studies from 5-11-93, 5-17-94, 5-16-95, 4-23-96, 4-25-96, 4-24-96, 4-27-96, 11-2-94
We established the following diagnosis:
Idiopathic encephalopathy, involution of left frontal and temporal lobe, right cerebellum, initial signs of dementia, aphasia, mild ataxia.
From the internist's point of view Mr. J.S.M. is a man older than his age, of athletic habit, safe in the somatic sense. Pulse regular 64-76 beats per minute, normal blood pressure 75-80 to 115-120 mm Hg. Heart tones were normal including sound and melody. Above the lungs there a clear percussion sound. Palpation of abdomen revealed no particularities. Skin was clear.
Since the last visit we admitted positive changes in his walk (more confident), speech (increased amount, fluency, readiness for communication), behavior (more active and completely included in all happening around), mood (optimistic, ready for humor, with no complaints), etc.
Tests:
01.07.96 Erythrocytes 4,2*1012/l, Hb 137 g/l, color index 0.9, thrombocytes 200*109/l, leukocytes 3.9*109/l, stab neutrophils 2%, segmented neutrophils 59%, eosinophiles 2%, lymphocytes 32%, monocytes 5%, ESR 3 mm/hr.
01.07.96 Bilirubin total 15.0 mmol/l, direct - neg., indirect 15.0 mmol/l, ALT 0.45 mmol/l, ACT 0.24 mmol/l, cholesterine 6. mmol/l, urea 12.5 mmol/l, creatinine 0.130 mmol/l.
01.07.96 ECG regular sinus rhythm, signs of mild changes of myocardium.
02.07.96 Examination by neurologist.
The state of the patient improved comparatively to previous examination. He had no complains. Focal organic changes of nerve system were not revealed - he is stable in the Romberg test, the adiadochokynesis is absent. The walk without particularities. Synkinesis of arm by the walk is satisfactory.
Considering effect of the treatment it is recommended to continue the therapy.
Mr. J.S.M. received a course of Cell Therapy. Action of the Cell suspensions was directed to the restitution of nerve connections, normalization of hematoencephalic barrier functions, removing of immune aggression against brain cells and to the restitution of micro circulation.
01.07.96 Implantation of the Cell suspension sample 3038 AM 522 subcutaneously in the frontal abdomen in two depots in amount 2 ml each.
02.07.96 Transplantation of the Cell suspension sample 3038 A 522 IV, amount 3.5 ml.
Implantation of the Cell suspension sample 3038 AM 522 subcutaneously in the frontal abdomen in two depots in amount 1.5 ml each.
03.07.96 Transplantation of the Cell suspension sample 3038 A 522 IV, amount 2.5 ml.
05.07.96 Transplantation of the Cell suspension sample 3038 A 117 IV, amount 2.6 ml.
Implantation of the Cell suspension sample 3038 AM 117 subcutaneously in the frontal abdomen in two depots in amount 1.3 ml each.
The Cell suspension samples 3038 AM 522, 3038 A 522, 3038 AM 117 and 3038 A 117 possess the mentioned above functional activity and are certified as follow:
| Bacterial sterility test |
Negative |
| Prenatal diagnostic |
| Test with cardiolipid antigen |
Negative |
| Anti - HIV1/HIV2 |
Negative |
| HBsAg |
Negative |
| Fetal diagnostic |
| Enzygnost Anti - HIV1/HIV2 |
Negative |
| HBsAg monoclonal |
Negative |
| Anti - HBc monoclonal |
Negative |
| Anti - CMV/IgG+IgM |
Negative |
| Anti - Rubella Virus/IgG |
Negative |
| Varicella/Zoster |
Negative |
| Toxoplasmosis/IgG |
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The treatment included also Cavinton sol 2.0
Sodium chloride sol. 0.9% - 100.0
IV 1 time per day, 5 injections.
From the 4.07.96 he also began treatment with Nootropil (Pyracetam) 0.4 x 2 times per day.
Recommendations:
1. The observed improvement of the patient's condition is good prognostic sign for the development of the curative effect. It is recommended that examination and the next course of treatment by means of Cell Therapy should be in October 1996 at our Cell Therapy Clinic.
2. We recommend to continue the started course of
Pyracetami (Nootropili) - preparation that improves metabolism in the large brain neurons - in total dosage 0.4 (1 capsule 3 times per day) and
Cavinton - preparation, that improves brain circulation, opens collateral vessels and restores micro circulation. The course may consist of 5-8 IV injections and then of 4-6 tablets per day within 2-3- months.
3. Among the additional therapy we recommend to continue only sleeping or sedative preparation before night sleep.
4. Before next visit to our clinic we recommend to make a fresh MRT-test.
Head of the Cell Therapy Clinic
of National Medical University and Center "EmCell"
professor Alexander Smikodoub.
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