Diagnosis:

Clinical AIDS; reconvalescent of pneumocystic pneumonia; chronic smoker's bronchitis; post-encephalitis condition; candidiasis of intestine and respiratory tracts; chronic gastritis in unstable remission; chronic cholecystitis in unstable remission.

Female patient 920034 "T", 37 years old, was admitted to the AIDS Department of the Research Institute of Epidemiology and Infectious Diseases on February 23, 1993.

Diagnosis: Clinical AIDS; reconvalescent of pneumocystic pneumonia; chronic smoker's bronchitis; post-encephalitis condition; candidiasis of intestine and respiratory tracts; chronic gastritis in unstable remission; chronic cholecystitis in unstable remission.

HIV infection was revealed in 1990; the patient was treated in Moscow till September, 1992. Her first stay with the AIDS Department of the Research Institute for Epidemiology and Infectious Diseases lasted from September 17 till October 26, 1992. The patient suffered from pneumocystic pneumonia.

On October 23, 1992, the patient was transferred to Intensive Care department with herpetic encephalitis; here, after the spinal puncture, spastic paraplegia and fallopian neuritis developed as a result of encephalitis.

The patient complained permanent headaches that were periodically aggravated, accompanied by nausea and sometimes by vomiting, as well as vertigo and periodic losses of consciousness. In addition, the patient suffered from cough accompanied by expectoration of small amounts of sputum, sensation of pain in bones and joints, weakness of muscles inof lower extremities (walking while holding a support), facial asymmetry (right-side neuritis of the facial nerve). Body temperature periodically increased up to 39 oC.

Objectively: skin and mucosa were pale and clean; small peripheral lymph nodes (up to 0.5 cm in diameter), movable, elastic, painless. Heart sounds were clear and rhythmic; respiration in lungs was rough, with diffused dry rales over the total surface.

The abdomen was soft and sensitive to palpation in the epigastric and right hypochondrium areas; stools and diuresis without any peculiarities.

The first transplantation of the cell suspension prepared from hematopoietic cells of human embryonic liver was carried out on March 4, 1993. The suspension was administered in an amount of 2.5 ml.

Immunology of patient T., female

04.03.93 1 transplantation

29.04.93 2 transplantation

05.11.93 3 transplantation

16.03.95 4 transplantation

16.04.96 5 transplantation

06.08.97 6 transplantation

After transplantation, positive progress was observed, i.e. improvement of general condition, emotional tonus and appetite. After several days, the cough decreased; it became easier for the patient to walk; the fever diminished. Rough respiration was still present in the lungs, however no rales was auscultated.

On April 29, 1993, repeated transplantation was carried out (the same sample, in amount of 2.5 ml). The patient was discharged on April 30, 1993 (for family reasons) in the satisfactory condition.

The patient stayed once again at the AIDS Department from May 13 till July 17, 1993. Headache, vertigo, pain in bones and joints were still present. Body temperature however did not increase; good appetite and sleep were observed; facial asymmetry diminished, cough disappeared; the patient could walk small distances without any support.

After her discharge on July 17, 1993, the patient stayed at home in the city of Odessa where she had herpes zoster of the hairy part of the head, with body temperature increase and encephalopathy. Breakouts continued till August 4, 1993.

On September 9, 1993, the patient was admitted to the AIDS Department with complaints of referred headache to right and left orbital cavities, pain and hinderedpainful and stiff movements in joints, increasing body temperature up to 37.3 to 38.2^oC, epigastric pain, and cough accompanied by expectoration of thick of sputum having a purulent nature. Rough respiration was auscultated in the lungs together with dry rales on both sides (October 19, 1993: pneumocysts in 48 % of visual fields).

On November 5, 1993, the third transplantation of the cell suspension of the same sample was carried out (1.5 ml). On November 9, 1993, cough decrease was noted; body temperature was 37.2^oC. No pneumocysts were revealed. The patient was discharged on November 11, 1993 in the satisfactory state.

Tables 1 through 6 show the results of laboratory and immunological tests.

Patients lives in city of Odessa and several times per year informs about her state. She is regularly examined once a year on the base of AIDS Department of the Kiev Research Institute for Epidemiology and Infectious Diseases by our doctors. She received altogether six Cell transplantations, last one in August 1997. For this time progress of AIDS symptoms was not observed. Among concomitant diseases there was candidiasis of mouth cavity, Frequent exacerbation of chronic bronchitis caused by common infections. She is active, is engaged in retail trade.

During all course of the disease until present time patient refused to take any antiviral preparations. She does not tolerate AZT as it was revealed when short 2 months course of AZT was prescribed in 1992 year.

At present, the state of the patient is satisfactory. Observation is being continued.

Head of the Cell Therapy Clinic
of National Medical University and Center "EmCell"
professor Alexander Smikodoub.