A.I. Smikodub. Yu.A. Grinevich, G.D. Bendyug, L.V. Radziyevskaya, V.V. Snigir, N.N. Khranovskaya, I.Yu. Glukhovskaya, V.S. Ivankova

Information concerning the ability of the transplanted fetal liver hemopoietic cells (FLHC) to restore hemopoiesis and immune system, as well as our former experimental investigations that had shown the FLHC ability to hamper metastasizing in experimental animals, gave us the ground to elaborate the scheme for complex treatment of the patients with solid tumors, which includes FLHC transplantation.

There were treated 32 patients with depression of hemopoiesis and immune system: 16 children from 2 to 15 years (13 with osteogenic sarcoma, 3 - with Wilms tumor) and 16 women with cervical cancer from 21 to 60 years old. Transplantation was performed with the use of 7 to 12 weeks of gestation cryopreserved FLHC. The volume of transplanted suspension was 2-4 ml with contents of the cells 0.1-4.0 x 108^ and contents of CFU-GEMM 0.5-9.0 x 103.

We ascertained that the use of FLHC transplantation in the scheme of oncology patients treatment inhibits the progressive cytopenia and improves the immune state and relative indices, with corresponding melioration of patients' general state. The near results convince of substantial advantage of the FLHC transplantation use in the complex treatment of the patients with the solid tumors to increase its joint efficacy.

A.I. Smikodub, Yu.A. Grinevich, G.D. Bendyug, L.V. Radziyevskaya, V.V. Snigir, N.N. Khranovskaya, I.Yu. Gluhovskaya, V.S. Ivankova Transplantation of cryopreserved fetal liver hemopoietic cells in complex treatment of cancer patients. Tumor biology, 1997, N 18, supply 2, p. 127. The 25th Anniversary Meeting of the International Society for Oncodevelopmental Biology and Medicine 19-24 September 1997, Montreux, Switzerland.