Smikodub A.I., Radzievskaya L.V., Snigir N.V.
Cell Therapy Clinic of National Medical University and Embryonic Tissues Center "EmCell"

Cytostatic neutropenia comprises one of the main factors that promote the devel- opment of infectious complications in oncologic patients. The complex of treatment of patients suffering from agranulocytosis caused by a standard chemotherapy was added with transplantation ofhemopoietic fetal cell suspensions. Used for transplan- tation were cryopreserved cell suspensions, each of them produced from human liver of one embryo having 7 to 12 weeks of gestation. One transplantation was used for each patient; amount of administered cells was 0.5 to 4.0*10^/ml, CFU- GM, 0.6 to 165*105, CFU-GEMM, 2.1 to 9.0*105.

Observed were 25 patients suffering from cytostatic agranulocytosis: 17 from acute leukosis, 2 leukemization of lymphoma, 1 from blastic crisis of chronic myeloblastic leukosis, 4 from solid tumors, and 1 from acute myelosane aplasia. In 19 patients cytostatic neutropenia was complicated by the development of infections.

On the ist-3rd day from transplantation, clinical improvement - decrease or nor- malization of the body temperature and decrease of manifestation of the intoxication syndrome - were observed in 14 out of 19 patients having infection symptoms.

An increase in amounts of leukocytes and neutrophils was recorded since the S^ day; however, a valid increase was revealed since the 1 ith day. On the 3Ta day, the amount of neutrophils was 0.40+0.12*109/1 (p>0.05), and on the llth day, 1.79+0.76*109/1 (p<0.05) as against 0.18+0.07*109/1 prior to transplantation.

An improvement of indices of erythrocytes and thrombocytes, as well as regression of infection manifestations was also noted.

Therapy appeared to be ineffective in five patients (20%).

Smikodub A.I., Radzievskaya L.V., Snigir N.V. TREATMENT OF CYTOSTATIC AGRANULOCYTOSIS BY MEANS OF TRANSPLANTATION OF FETAL LIVER HEMOPOIETIC CELLS Fourth International Congress of Cell Transplantation Society. Montreux / Switzerland, March 1999. Cell Transplantation, v.8, n.2. 1999, p. 123.