Smikodub Alexander, Bushneva Victoria
Cell Therapy Clinic of National Medical University and Embryonic Tissues Center "EmCell"

30 patients suffering from medium and severe forms of chronic relapsing nonspecific ulcerative colitis (21 patients) and Crohn's disease (9 patients) in the acute attack phase were subjected to intravenous transplantation of fetal hemopoietic stem cells. Remission by 14 to 30 days was observed in 43% patients;
incomplete remission, in 30% patients, and absence of this effect, in 27% patients. Transplantation was not accompanied by of any side reactions. After transplantation, observed in 40% patients was syndrome of the early posttransplantation improvement, as well as syndrome of psychophysiological changes (in 80% cases). In patients who transferred to the remission phase, a decrease in the defecation frequency from 8+2 down to 2+1 times, disappearance or sharp decrease in the amount of admixtures to stools, normalization of body temperature, and weight gain were observed.

Endoscopy carried out after 1 and 3 months revealed disappearance of hyperemia and edema of mucous coats, contact hemorrhagic diathesis, absence of vascular pattern, absence or distortion of haustra, disappearance of inflammatory polyps, and decrease in the length of intestine injury. Also disappeared roentgenologic symptoms of large intestine injury such as serration, double loop, absence of haustra, straightness, narrowing of large intestine, as well as symptom of filling defects.

Normalization of erythrocytes and hemoglobin contents was noted by 15-20 day (p<0.05). Immune system revealed two types of behavior: quick normalization within 2-3 weeks, and sharp decrease of cell antibodies, that interrupted inflammatory process, with slow restoration of immunity by 2-3 months.

Duration of remission observed was 294+57 days.

Smikodub Alexander, Bushneva Victoria Treatment of patients suffering from autoimmune intestinal diseases with the use of fetal cell suspensions Fourth International Congress of Cell Transplantation Society. Montreux / Switzerland, March 1999. Cell Transplantation, v.8, n.2. 1999, p. 122.