Smikodoub Alexander, Pilipchak Elena
Cell Therapy Clinic of National Medical University and Embryonic Tissues Center "EmCell"

Immune substituting therapy by means of transplantation of fetal cell suspensions having high contents of stem cells of hemopoiesis was carried out in 38 HIV infected patients, among which one man was a carrier, 8 patients suffered from AIDS-AC, and 29 from AIDS. Average age of patients was 35 years. Transplantations were carried out by intravenous and subcutaneous administration of fetal cell suspensions. All patients easily agreed to transplantations and endured them satisfactorily

Generally, during two weeks after transplantation an improvement was observed in patients: energy increase, 45%; improvement of sleep, 39%;

decrease of ache and pain, 13%; decrease in irritation, 32%; increase of work capability, 18%; decrease offatiguability, 37%; improvement of spirits, 55%.

Considerable and statistically valid improvement of CD3+, CD4+ and CD8+ indi- ces was observed on the 12th day and remained during 2 months. The CD4+/CD8+ ratio increased during the first week; it however decreased later on. We observed maintenance of the increased level of CD3+ and CD4+ during 3 to 8 and even 18 months.

In 17 (77%) patients suffering from astheno-neurotic syndrome, observed were substantial improvement of general state. In patients suffering from paresis and neuropathy, the scope of movements of injured extremities increased.

In 10 patients, pathology of the respiratory system was observed (bronchitis, pneu- monia, pulmonary tuberculosis). 2 weeks after transplantation, against the back- ground of standard therapy, observed in these patients was a decrease of the bron- choobstructive syndrome; in patients suffering from tuberculosis, general state im- proved and decreased the body temperature, patients.

Smikodoub Alexander, Pilipchak Elena NEW METHOD OF IMMUNE SUBSTITUTING THERAPY WITH THE USE OF FETAL CELLS IN CASES OF HIV INFECTION (AIDS) Fourth International Congress of Cell Transplantation Society. Montreux / Switzerland, March 1999. Cell Transplantation, v.8, n.2. 1999, p. 120.