Smikodub A.I., Snigir N.V., Radzievskaya L.V., Grinevich Y.A., Bendug G.D.

Observed were 16 patients with acute leukoses and neutropenia; 32- with solid tumors (16 with cervical carcinoma subjected to combined radiotherapy; 13 children with osteogenic and chondroid sarcoma, 3 children with Wilms tumor). Suspensions having high contents of stem cells of hemopoiesis were used (nucleated cells - 50- 300xl06/ml; CFU-GM, 0.6 -165xl03; CFU GEMM, 2.1 - 9.0xl03).

Upon treatment, the patients better endured cytostatic therapy;percentage of complications was reduced; positive dynamics of infection process involving neutropenia and hemorrhagic syndrome was observed. Substantial increase in the amounts of leukocytes, thrombocytes and erythrocytes in the peripheral blood was observed on the 11th and 13th day from Cell Therapy. In cervical carcinoma patients, peripheral blood induces improved during the second week in spite of keeping radiotherapy. In patients with solid tumors, also observed was increased in the total amount of lymphocytes, T-lymphocytes, and NK-cells. Cell Therapy caused no side reactions.

Smikodub A.I., Snigir N.V., Radzievskaya L.V., Grinevich Y.A., Bendug G.D. EXPERIENSE IN TREATMENT OF PATIENTS SUFFERING FROM LEUKOSES AND SOLID TUMORS BY FETAL STEM CELLS Abstracts of the 10th International Symposium Supportive Care in Cancer, San Antonio . Supportive Care in Cancer, 1998, vol. 6, No. 2, p. 166-10.